作者认为环孢霉素不仅能抑制自家免疫现象,还可缓解慢性肝病的硬化改变。为了解释这一假设,作者用小剂量环孢霉素治疗肝毒素诱发的慢性肝损伤。资料和方法作者在 Sprague-Dawley 鼠作实验,分成6个组:(1)第1组:22只。肌注四氯化碳(CCl_4)1 ml/kg,每周两次,共6周,每日口服环孢 The authors believe that cyclosporine can not only inhibit the phenomenon of self-immunity, but also alleviate the hardening of chronic liver disease changes. To explain this hypothesis, the authors used low-dose cyclosporine to treat liver-toxin-induced chronic liver injury. Materials and Methods The authors performed experiments in Sprague-Dawley rats divided into six groups: (1) Group 1: 22. Intramuscular injection of carbon tetrachloride (CCl_4) 1 ml / kg, twice a week for 6 weeks, daily oral cyclosporine