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目的分析甲状腺球蛋白抗体(TgAb)阳性时分化型甲状腺癌(DTC)患者荷瘤状况,间接评价阳性TgAb对甲状腺球蛋白(Tg)临床价值的影响。方法收集52例共69例次TgAb阳性DTC患者,对其131I治疗后的扫描结果进行分析,结合X线、CT、MRI、B超及临床随访等资料进行综合判断患者转移病灶的状况。有转移灶者为阳性。结果 Tg≥10μg/L、10~2.0μg/L、2~0.1μg/L、≤0.1μg/L 4组转移灶阳性率分别为80.95%、53.84%、58.82%、50.00%。组间差异无统计学意义(P>0.05)。结论 TgAb阳性时,转移灶阳性率与Tg水平无相关性,阳性TgAb削弱了Tg的临床价值。
Objective To analyze the tumor-bearing status of thyroid globulin antibody (TgAb) -positive patients with differentiated thyroid carcinoma (DTC) and evaluate the effect of positive TgAb on the clinical value of thyroglobulin (Tg) indirectly. Methods A total of 52 patients with TgAb-positive DTCs were collected from 52 patients. The results of 131I treatment were analyzed. Combined with X-ray, CT, MRI, B-ultrasound and clinical follow-up data, the status of metastatic lesions was evaluated. Those who have metastases are positive. Results The positive rates of metastasis of Tg ≥ 10μg / L, 10 ~ 2.0μg / L, 2 ~ 0.1μg / L and ≤ 0.1μg / L were 80.95%, 53.84%, 58.82% and 50.00% respectively. There was no significant difference between groups (P> 0.05). Conclusion The TgAb positive, the positive rate of metastasis and Tg no correlation, positive TgAb weakened the clinical value of Tg.