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目的探讨乳腺粒细胞肉瘤(GS)的临床病理特征、免疫组化及鉴别诊断。方法回顾性分析3例乳腺粒细胞肉瘤的临床及病理资料,并辅以免疫组化分析。结果 3例患者均为育龄期女性,均因偶然发现乳腺无痛性肿块就诊。组织学显示,瘤组织由较一致的原始细胞组成,弥散浸润,细胞中等大小,呈圆形、短梭形及不规则形等,部分胞质呈嗜酸性颗粒状;瘤细胞核不规则,核仁明显,核分裂象易见。免疫组化:瘤细胞MPO和CD43(+),而CD3、CD20、CD30、CK、EMA和E-cad均(-)。随访2例,1例病情稳定,1例死亡,另外1例失访。结论发生于乳腺的粒细胞肉瘤罕见,预后差。组织学上需与乳腺浸润性小叶癌、非霍奇金淋巴瘤、原始神经外胚层瘤(PNET)等鉴别。
Objective To investigate the clinicopathological characteristics, immunohistochemistry and differential diagnosis of granulocytic sarcoma (GS) in children. Methods The clinical and pathological data of 3 cases of granulocystic sarcoma were retrospectively analyzed and analyzed by immunohistochemistry. Results All three patients were women of childbearing age. All were diagnosed with painless mass by chance. Histology showed that the tumor tissue consisted of more consistent primitive cells, diffused and infiltrated, and the cells were of medium size, round, short fusiform and irregular shape. Some of the cytoplasm was eosinophilic granules. The tumor nuclei were irregular, Obviously, mitotic figures are easy to see. Immunohistochemistry: tumor cells MPO and CD43 (+), while CD3, CD20, CD30, CK, EMA and E-cad (-). Two cases were followed up, one was stable, one died and the other was lost. Conclusion The granulocytic sarcoma occurred in the breast is rare and the prognosis is poor. Histologically, it needs to be differentiated from breast invasive lobular carcinoma, non-Hodgkin’s lymphoma and primitive neuroectodermal tumor (PNET).