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自1980年以来,Chen等在研究活细胞线粒体定位中,发现肿瘤细胞线粒体带有较强的膜电位(mitochondrial membrane potential)对某些阳离子化合物如罗丹明123(Rhodamine123,Rh123)有较强的亲和能力,并观察到此类化合物具有抑制癌细
Since 1980, Chen et al. have studied the mitochondrial localization of living cells and found that the mitochondrial membrane potential of mitochondria in tumor cells has a strong affinity for certain cationic compounds such as Rhodamine 123 (Rh123). And ability, and observed that such compounds have the ability to inhibit cancer