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目的 :探讨α1 微球蛋白等对 2型糖尿病、高血压病、高血压病并 2型糖尿病患者早期诊断的价值。方法 :对血、尿α1 微球蛋白、β2 微球蛋白、尿白蛋白进行检测。结果 :显示高血压病组尿α1 微球蛋白与正常对照组比较差异有显著意义 (P <0 0 5 ) ,各疾病组尿白蛋白与对照组比较差异有显著意义 (P <0 0 5 )。结论 :提示尿α1 微球蛋白、白蛋白可作为高血压病、2型糖尿病早期肾损伤的敏感指标 ,但血尿 β2 微球蛋白对早期肾损伤的诊断无价值。
Objective: To investigate the value of α1 microglobulin in the early diagnosis of type 2 diabetes mellitus, hypertension, hypertension and type 2 diabetes mellitus. Methods: blood, urine α1 microglobulin, β2 microglobulin, urinary albumin were detected. Results: Urine α1 microglobulin in hypertensive patients showed significant difference compared with the normal control group (P <0.05), and there was significant difference between the groups of urinary albumin and control group (P <0.05) . Conclusion: The urinary α1 microglobulin and albumin may be used as sensitive markers of hypertension and type 2 diabetes early renal injury, but the hematuria β2 microglobulin is of little value in the diagnosis of early renal injury.