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目的分析厦门市预防接种不良事件(AEFI)发生特征,评价疫苗的安全性和AEFI监测质量。方法根据《全国疑似预防接种异常反应监测方案》对监测系统相关指标进行分析。结果厦门市2008-2010年报告AEFI病例106例,报告发病率19.81/100万;病例主要集中在8、9、11月(50.0%);以1岁以下儿童为主(67.0%);主要为接种百白破疫苗、麻疹疫苗及流脑A群疫苗引起(71.7%);一般反应占55.7%,异常反应34.0%,偶合症9.4%;症状较轻,主要以发热、红肿、皮疹为主,占77.4%。结论通过培训及督导,增强监测敏感性,AEFI平均发生率在预期范围之内,疫苗接种安全可靠。
Objective To analyze the characteristics of AEFI in Xiamen and evaluate the safety of vaccine and the quality of AEFI monitoring. Methods According to “National Suspected Vaccination Abnormal Response Monitoring Program” to analyze the relevant indicators of the monitoring system. Results AEFI cases were reported in 106 cases from 2008 to 2010 in Xiamen City, with a reported incidence of 19.81 / 1 million. The cases were mainly concentrated in August, September and November (50.0%), mainly children under 1 year old (67.0%), mainly Inoculation of diphtheria toxin vaccine, measles vaccine and meningitis group A vaccine (71.7%); general reaction accounted for 55.7%, abnormal response 34.0%, coupling 9.4%; mild symptoms, mainly in fever, redness, rash, Accounting for 77.4%. Conclusions The average incidence of AEFI is within the expected range through training and supervision so as to enhance monitoring sensitivity. Vaccination is safe and reliable.