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干扰素(INF)已用于治疗慢性乙型肝炎病人。本文旨在明确INF-β治疗慢性活动性肝炎(慢活肝)期间对肝细胞和蛋白合成的作用。材料和方法:5例HBeAg阳性的成年慢活肝病人,静脉注射INF-β,每天3×10~(6U),3天;每天6×10~6U,4天;每天3×10~6U,3周;总量102×10~6U。另5俐HBeAg阳性慢活肝病人在四周内未用任何药物。在INF治疗前、治疗期间每周一次和治疗后2或4周测血ALT、AST、AI-p、Ch-E和白蛋白。用RIA法检测HBsAg、抗-HBs、HBeAg、抗-HBe和抗HBc。用Kaplan法测DNA-p活性。这10例的ALT和AST升高至少有一年,进入试验时HBeAg阳性和DNA-p阳性每例病人分别于治疗前、停止治疗前、治疗后的6个月和治疗后的12个月(3例)行肝活检。标本在光镜及电镜下检查。
Interferon (INF) has been used to treat chronic hepatitis B patients. This article aims to clarify the effect of INF-β on hepatocyte and protein synthesis during treatment of chronic active hepatitis (slow-acting liver). MATERIALS AND METHODS: Five adult HBeAg-positive chronic active liver cancers were infused intravenously with INF-β 3 × 10 ~ (6U) daily for 3 days, 6 × 10 ~ 6U daily for 4 days, and daily 3 × 10 ~ 6U daily. 3 weeks; total 102 × 10 ~ 6U. Another 5 Li HBeAg-positive slow liver patients within four weeks without any drugs. ALT, AST, AI-p, Ch-E and albumin were measured before INF treatment, once weekly during treatment and 2 or 4 weeks after treatment. HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were detected by RIA. DNA-p activity was measured by Kaplan method. The ALT and AST were elevated for at least one year in each of the 10 patients. Before entering the trial, HBeAg positive and DNA-p positive were observed in each patient before treatment, before treatment, 6 months after treatment, and 12 months after treatment (3 Example) Liver biopsy. Specimens were examined under light and electron microscopy.