Preparation of new tissue engineering bone-CPC/PLGA composite and its application in animal bone def

来源 :中南大学学报(英文版) | 被引量 : 0次 | 上传用户:aiwoba1215
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
To investigate the feasibility of implanting the biocomposite of calcium phosphate cement (CPC)/polylactic acid-polyglycolic acid (PLGA) into animals for bone defects repairing, the biocomposite of CPC/PLGA was prepared and its setting time, compressive strength, elastic modulus, pH values, phase composition of the samples, degradability and biocompatibility in vitro were tested. The above-mentioned composite implanted with bone marrow stromal cells was used to repair defects of the radius in rabbits. Osteogenesis was histomorphologically observed by using an electron-microscope. The results show that compared with the CPC, the physical and chemical properties of CPC/PLGA composite have some differences in which CPC/PLGA composite has better biological properties. The CPC/PLGA composite combined with seed cells is superior to the control in terms of the amount of new bones formed after CPC/PLGA composite is implanted into the rabbits, as well as the speed of repairing bone defects. The results suggest that the constructed CPC/PLGA composite basically meets the requirements of tissue engineering scaffold materials and that the CPC/PLGA composite implanted with bone marrow stromal cells may be a new artificial bone material for repairing bone defects because it can promote the growth of bone tissues.
其他文献
期刊
期刊
一、教学内容rn数学绘本《帽子戏法》、平板基础使用法、卡纸帽制作.rn二、教学对象rn三年级学生.rn三、教学目标rn1.以数学课程为主,融合信息、美术课程知识,实现学科整合教
期刊
期刊
期刊
期刊
期刊
期刊
“安全生产周”活动是安全生产宣传教育一项重要的、定期的活动。“安全生产周”活动的发展与我国安全生产工作的发展是紧密相联的,经历了一个不断探索、完善、规范的过程。从
期刊