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目的 研究c erbB 2和nm2 3基因蛋白在乳腺肿瘤中的表达情况及临床意义。方法应用免疫组化S P法 ,对 131例乳腺良恶性肿瘤进行c erbB 2和nm2 3基因蛋白检测 ,对其中 10 2例乳腺癌进行雌激素受体 (ER)和孕激素受体 (PR)检测。结果 c erbB 2蛋白在导管内癌、Paget病及浸润性导管癌中呈高表达 ;nm2 3蛋白在浸润性小叶癌中呈高表达。c erbB 2与淋巴结转移及PR呈正相关 ;nm2 3与乳腺癌患者的年龄、组织学分级、淋巴结转移及ER和PR密切相关。结论c erbB 2呈阴性表达、而nm2 3呈阳性表达时乳腺癌患者的预后最好。
Objective To study the expression of c erbB 2 and nm23 gene in breast cancer and its clinical significance. Methods Immunohistochemical SP method was used to detect c erbB 2 and nm23 gene in 131 cases of breast benign and malignant tumors. The estrogen receptor (ER) and progesterone receptor (PR) were detected in 102 cases of breast cancer . Results c erbB 2 protein was highly expressed in ductal carcinoma, Paget disease and invasive ductal carcinoma. Nm23 protein was highly expressed in invasive lobular carcinoma. c erbB 2 positively correlated with lymph node metastasis and PR, while nm 2 3 was closely related with age, histological grade, lymph node metastasis and ER and PR in patients with breast cancer. Conclusions c erbB 2 is negative, while the positive expression of nm23 is the best prognosis for breast cancer patients.