胰腺癌是一种起病隐匿、早期诊断困难、发展迅速并且预后极差的消化系统恶性肿瘤。胰腺癌诊治的关键是早期发现和确诊，进行相关标志物的风险评估，并给予及时的干预以预防恶化，这些都将对胰腺癌的诊治产生正面积极的作用。环状RNA(circRNAs)是一种共价闭合环状结构的非编码RNA，具有结构稳定、高度保守性及特异性表达的特性，是近年来继微小RNA(miRNA)、长链非编码RNA(lncRNA)之后研究较为热门的非编码RNA，它在许多疾病包括癌症的发生发展中都起重要作用。circRNAs可作为竞争性内源RNA(ceRNAs)结合miRNA，从而调控基因的表达，或结合RNA相关蛋白发挥相应的生物学功能，在肿瘤的发生发展中扮演了重要的角色，有一定的潜力成为肿瘤诊断的生物标志物及治疗靶点。但circRNAs在胰腺癌中的作用机制的研究仍处于起步阶段，本文结合国内外最新研究成果，就circRNAs作为胰腺癌诊断及判断预后标志物及治疗靶点的相关研究作一综述。“,”Pancreatic cancer is a malignant tumor of the digestive system with insidious onset, difficult early diagnosis, rapid development and extremely poor prognosis. The key to the diagnosis and treatment of pancreatic cancer is the need for early detection and diagnosis, the risk assessment of related markers and the early and timely intervention to prevent its deterioration, which will all have a positive effect on the diagnosis and treatment of pancreatic cancer. Circular RNA is a kind of non-coding RNA with covalently closed circular structure. It has the characteristics of stable structure, high conservation and specific expression. It is more popular than microRNAs and long non-coding RNAs in recent years as a kind of non-coding RNA, and it has played an important role in the occurrence and development of many diseases. Circular RNA can be used as competing endogenous RNAs (ceRNAs) combined with miRNA to regulate gene expression or combined with RNA-related proteins to perform biological functions. It plays an important role in the occurrence and development of tumors and it is also expected to become a biomarker for tumor diagnosis. The research on the mechanism of circular RNAs in pancreatic cancer is still in its infancy. Based on the latest research results at home and abroad, this article reviews the relevant research on circular RNAs as a biomarker for the diagnosis and prognosis of pancreatic cancer and treatment targets for pancreatic cancer.