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目的探讨头痛宁胶囊与尼莫地平联合应用治疗外伤性蛛网膜下腔出血(tsAH)的疗效。方法选择240例tSAH病例随机分为对照组及治疗I、Ⅱ、Ⅲ组,每组60例。对照组采用常规治疗(止血、脱水、激素及促神经功能恢复药等)治疗I、Ⅱ、Ⅲ组均在常规治疗基础上,分别采用头痛宁胶囊,尼莫地平及头痛宁胶囊联合尼莫地平治疗。结果在头痛症状减轻程度及持续时间、脑膜刺激征持续时间、脑脊液恢复正常时间方面。治疗Ⅲ组效果均优于其他3组(P<0.05)。结论头痛宁胶囊与尼莫地平联合治疗tSAH,对患者临床症状的改善优于单独使用头痛宁胶囊或尼莫地平治疗,值得临床推广应用。
Objective To investigate the curative effect of combination of Totaining capsule and nimodipine on traumatic subarachnoid hemorrhage (tsAH). Methods Totally 240 cases of tSAH were randomly divided into control group and treatment group Ⅰ, Ⅱ, Ⅲ, 60 cases in each group. The control group were treated with conventional treatment (hemostasis, dehydration, hormone and nerve function recovery medicine, etc.) in the control group I, Ⅱ, Ⅲ were treated on the basis of conventional treatment, respectively, using the capsule Tongmaining, nimodipine and tengtongning capsule combined with nimodipine treatment. Results in the reduction of headache symptoms and duration, duration of meningeal irritation, cerebrospinal fluid recovery time. The effect of treatment group Ⅲ was better than the other three groups (P <0.05). Conclusion Tongtongning capsule combined with nimodipine in the treatment of tSAH has better clinical symptoms than those treated with Touttongning capsule or nimodipine alone and is worthy of clinical application.