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目的研究高血压危险因素对高血压患病率的影响。方法7 917例受试者根据体重指数(BM I)和腰围分成4组:1组(腹型肥胖):BM I≥25并且男性腰围≥90 cm或女性腰围≥80 cm;2组(外周型肥胖):BM I≥25并且男性腰围<90 cm或女性腰围<80 cm;3组(正常体重代谢性肥胖MONW):BM I<25并且男性腰围≥90 cm或女性腰围≥80 cm;4组(正常对照):BM I<25并且男性腰围<90 cm或女性腰围<80cm。观察指标包括血压、空腹血糖、餐后2 h血糖、血脂、空腹胰岛素和血尿酸,并计算胰岛素抵抗指数(HO-MA-IR)和胰岛素分泌指数(HOMA-IS)。按IDF2005 MS诊断标准计算代谢综合征(MS)患病率。结果(1)本次调查高血压患者2 288人,高血压患病率为28.9%。(2)高血压总患病率男性高于女性(30.98%vs26.12%),且患病率随年龄增加而增加。(3)各型肥胖高血压患病率按大小排列依次为腹型肥胖、外周型肥胖、MONW和正常组。(4)偏相关分析显示,控制FIns的影响后,SBP和DBP与HOMA-IR的关系仍然存在,但控制HOMA-IR的影响后,SBP和DBP与FIns无相关性。控制HOMA-IR变量后SBP和DBP仍然与PBG显著正相关,但DBP与FBG无相关;控制TCH、LDL和HDL的影响后,SBP和DBP与TG仍然显著正相关。而控制TG的影响后,SBP和DBP与LDL仍然显著正相关,与TCH无相关。结论广西南宁市部分事业单位人群高血压患病率高并随年龄而增加;其他主要危险因素包括BM I、腰围、TG、PBG和LDL。
Objective To study the impact of hypertension risk factors on the prevalence of hypertension. Methods 7 917 subjects were divided into 4 groups based on body mass index (BM I) and waist circumference: Group 1 (abdominal obesity): BM I ≥ 25 and waist circumference ≥ 90 cm for men or ≥ 80 cm for women; Obesity): BM I ≧ 25 and male waist circumference <90 cm or female waist circumference <80 cm; 3 groups (normal body weight metabolic obesity MONW): BM I <25 and male waist circumference ≥90 cm or female waist circumference ≥80 cm; (Normal control): BM I <25 and male waist circumference <90 cm or female waist circumference <80 cm. Observations included blood pressure, fasting blood glucose, postprandial blood glucose, lipids, fasting insulin and serum uric acid. Insulin resistance index (HO-MA-IR) and insulin secretion index (HOMA-IS) were calculated. The prevalence of metabolic syndrome (MS) was calculated according to the IDF 2005 MS diagnostic criteria. Results (1) The survey of 2 288 hypertensive patients, the prevalence of hypertension was 28.9%. (2) The prevalence of hypertension was higher in males than in females (30.98% vs26.12%), and the prevalence increased with age. (3) The prevalence of various types of obesity and hypertension were ranked as follows: abdominal obesity, peripheral obesity, MONW and normal group. (4) Partial correlation analysis showed that the relationship between SBP and DBP and HOMA-IR still existed after controlling the influence of FIns, but there was no correlation between SBP and DBP and FIns after controlling the influence of HOMA-IR. SBP and DBP remained significantly positively correlated with PBG after control of HOMA-IR, but DBP had no correlation with FBG. After controlling the effects of TCH, LDL and HDL, there was still a significant positive correlation between SBP and DBP. However, after controlling the influence of TG, SBP and DBP are still significantly and positively correlated with LDL, but not with TCH. Conclusions The prevalence of hypertension in some institutions in Nanning City, Guangxi Province is high and increases with age. Other major risk factors include BM I, waist circumference, TG, PBG and LDL.