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目的探讨醒脑静联合还原型谷胱甘肽注射液治疗急性苯二氮类药物中毒患者的临床疗效。方法将120例急性苯二氮类药物中毒患者随机分为观察组与对照组各60例。对照组给予贝美格联合维生素C注射液静脉点滴,观察组给予醒脑静注射液与还原型谷胱甘肽联合治疗。检测2组治疗前后血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、肌钙蛋白Ⅰ(cTnⅠ)、神经元特异性烯醇化酶(NSE)、血浆钠尿肽(BNP)与谷草转氨酶(AST)、胱抑素C(Cys C)、肌酐(SCr)水平,记录2组自主意识完全恢复时间及肺水肿、吸入性肺炎、机械通气、上消化道出血与缺血性脑卒中发生率。结果治疗后,观察组血清AST、CysC、SCr、cTnⅠ、BNP、NSE、CRP、IL-6水平均明显低于对照组(P均<0.05),患者自主意识完全恢复时间明显短于对照组(P<0.05),肺水肿、吸入性肺炎、机械通气、上消化道出血以及缺血性脑卒中发生率均明显低于对照组(P均<0.05)。结论醒脑静联合还原型谷胱甘肽注射液治疗急性苯二氮类药物中毒患者具有较好疗效,其机制与下调机体炎性反应水平有关。
Objective To investigate the clinical effect of Xingnaojing combined with reduced glutathione injection in the treatment of acute benzodiazepine poisoning patients. Methods A total of 120 patients with acute benzodiazepine poisoning were randomly divided into observation group and control group with 60 cases each. The control group received intravenous injection of pimeclin and vitamin C injection, and the observation group received Xingnaojing injection combined with reduced glutathione. Serum C-reactive protein (CRP), interleukin-6 (IL-6), troponin Ⅰ (cTnⅠ), neuron specific enolase (NSE) and plasma natriuretic peptide (BNP) (AST), cystatin C (Cys C) and creatinine (SCr) were measured. The complete recovery time of autonomic consciousness and pulmonary edema, aspiration pneumonia, mechanical ventilation, upper gastrointestinal bleeding and ischemic brain were recorded Stroke incidence. Results After treatment, the levels of AST, CysC, SCr, cTnⅠ, BNP, NSE, CRP and IL-6 in the observation group were significantly lower than those in the control group (all P <0.05) P <0.05). The incidences of pulmonary edema, aspiration pneumonia, mechanical ventilation, upper gastrointestinal bleeding and ischemic stroke were significantly lower than those of the control group (all P <0.05). Conclusion Xingnaojing combined with reduced glutathione injection in patients with acute benzodiazepine poisoning has a good effect, and its mechanism of down-regulation of inflammatory response in the body.