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目的探讨异常核型的急性非淋巴细胞白血病(ANLL)患者近期疗效。方法R显带法进行核型分析。观察组和对照组分别含111例核型异常和69例核型正常ANLL患者。结果异常核型组完全缓解(CR)率明显低于正常核型组(44.14%对65.22%;P<0.01)。非t(8;21)核型异常组的ANLL患者CR率明显低于正常核型组(28.57%对65.22%;P<0.005)。结论伴复杂核型异常的ANLL疗效较差。
Objective To investigate the short-term curative effect of patients with abnormal karyotype of acute non-lymphocytic leukemia (ANLL). Methods R banding karyotype analysis. The observation group and control group were 111 cases of karyotype abnormalities and 69 cases of normal karyotype ANLL patients. Results The complete remission (CR) rate of abnormal karyotype group was significantly lower than that of normal karyotype group (44.14% vs 65.22%; P <0.01). The CR rate in ANLL patients with non-t (8; 21) karyotype abnormalities was significantly lower than that in normal karyotypes (28.57% vs 65.22%; P <0.005). Conclusion ANLL with complicated karyotype is not effective.