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目的:构建基于微信的新型冠状病毒肺炎疫情基层防控继续教育平台(以下简称“微信培训平台”)，评估平台的应用效果。方法:微信培训平台包括5类课程。分析2020年2月19日至3月5日主动注册登陆微信培训平台的广州市基层医务人员的学习、考试情况和实际产生成本，并与现场培训估算成本进行比较，采用卡方检验、非参数检验和logistic回归方法进行数据分析。结果:基层医务人员共有26 939人次参加培训和52 748人次通过考试，对5类课程的评价主要是“实用”。基层医务人员参加微信培训平台完成所有课程的学习、复习和通过考试的累计时间是96分钟，而参加相同课程学习和考试的现场培训所需时间为480分钟。5类课程考试成绩的全部满分率为42.3%(22 309/52 748)，“现场流行病学”满分率最高[47.3%(5 869/12 421)]，学习人次数最多(12 421人次)，考试用时最长(每人次4.8分钟)。logistic回归分析显示，考试类型和考试用时对满分率都有影响。现场培训成本(473.81万元)是微信培训平台成本(9.96万元)的47.6倍。结论:微信培训平台有助于基层医务人员主动学习，并通过反复学习和考试掌握培训内容；与现场培训相比，微信培训平台的成本效益较为显著。“,”Objective:To implement a Wechat-based continuing medical education system (Wechat-based CMES) for health-care workers (HCWs) in grass-roots control and prevention for COVID-19 and evaluate its effectiveness.Methods:Five types of e-courses were designed and uploaded to the system. Data for learning and passing quizzes of HCWs who actively logged in the system with Wechat accounts from Feb 19th to Mar 5th, 2020 was collected and analyzed by chi square test, non-parametric test and logistic regression. The actual cost of the Wechat-based CMES was compared to the estimated cost of the on-site CME as well.Results:The person time of HCWs who participated in studying e-courses and passed the quizzes were 26 939 and 52 784 respectively. The comment from HCWs on the e-courses was mainly “practical” . HCWs spent 96 minutes by an accumulate time for learning, reviewing and passing the quizzes using the Wechat-based CMES, however, they would have to spend 480 minutes for the same learning and passing the quizzes using the on-site CME. The full mark rate of quizzes of the 5 types of courses is 42.3% (22 309/52 748). Of the five courses, the course “field epidemiological investigation” has the highest full mark rate of 47.3% (5 869/12 421), the most learners of 12 421 person times and the longest exam time of 4.8 minutes per person time. Logistic regression shows that both quiz types and quiz time have effect on the full mark rate. The costs of on-site CME(4.73 thousand) was 47.6 times than that of the wechat-based CMES(0.996 thousand).Conclusions:The use of Wechat-based CMES helps HCWs to learn actively and master the training content through repeated study and examination. Compared with the on-site CME, the Wechat-based CMES is more cost-effective.