论文部分内容阅读
目的观察阿苯达唑和地塞米松治疗广州管圆线虫病的效果,探讨药物的作用机制。方法:以Balb/c小鼠为动物模型,在感染后不同时间,用不同剂量的阿苯达唑治疗,并设立地塞米松进行联合治疗对照组。小鼠于感染后第22d解剖,计数脑组织中存活虫体,以减虫数统计药物疗效;同时观察脑组织切片病理变化;应用透射电镜观察阿苯达唑对虫体超微结构的影响,对药物的作用机制进行探讨。结果阿苯达唑为治疗广州管圆线虫病的有效药物,感染早期用药效果显著。杀虫药和地塞米松的合用可有效减轻脑部炎症反应。阿苯达唑主要通过虫体体壁及肠道吸收而发挥作用。结论阿苯达唑和地塞米松的联合应用可以有效治疗广州管圆线虫病。
Objective To observe the efficacy of albendazole and dexamethasone in treatment of angiostrongyliasis in Guangzhou and to explore the mechanism of action of the drug. Methods: Balb / c mice were used as animal models. Different doses of albendazole were administered at different times after infection. Dexamethasone was given to the control group. The mice were dissected on the 22nd day after infection and the survivals in the brain tissue were counted. The curative effect of the drug was counted by decreasing the number of worms. The pathological changes of the brain slices were also observed. The effects of albendazole on the ultrastructure of the worms were observed by transmission electron microscope The mechanism of action of drugs is discussed. Results Albendazole was an effective drug for the treatment of angiostrongyliasis in Guangzhou. Insecticide and dexamethasone combination can effectively reduce brain inflammation. Albendazole mainly through the parasitic body wall and intestinal absorption and play a role. Conclusions The combination of albendazole and dexamethasone can effectively treat angiostrongyliasis in Guangzhou.