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目的探讨奥拉西坦联合丹红治疗老年脑梗死的临床疗效。方法选取长沙市精神病医院2012年4月—2013年4月收治的102例老年脑梗死患者,应用数字分配法将其分为研究组(51例)与对照组(51例)。患者均首先应用常规内科治疗,在此基础上,对照组患者单独应用丹红治疗,研究组患者应用奥拉西坦联合丹红治疗。比较两组患者的临床疗效、治疗前后的神经功能缺损评分及血液流变学指标。结果研究组患者的总有效率高于对照组,治疗后研究组神经功能缺损评分高于对照组,全血浆黏度、血小板聚集率以及血栓形成系数均低于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论奥拉西坦联合丹红治疗老年脑梗死,能够显著改善患者的神经功能缺损评分与血液流变学,提高临床疗效,减少不良反应的发生。
Objective To investigate the clinical efficacy of oxiracetam combined with Danhong in the treatment of senile cerebral infarction. Methods A total of 102 elderly patients with cerebral infarction who were admitted to Changsha Psychiatric Hospital from April 2012 to April 2013 were divided into study group (51 cases) and control group (51 cases) by digital distribution method. Patients were the first to use conventional medical treatment, on this basis, the control group of patients treated with Dan Hong alone, the study group of patients with Oxiracetam combined Danhong treatment. The clinical efficacy, neurological deficit scores and hemorheological indexes before and after treatment were compared between the two groups. Results The total effective rate of study group was higher than that of control group. After treatment, the neurological deficit score of study group was higher than that of control group. The whole plasma viscosity, platelet aggregation rate and thrombosis coefficient were all lower than those of control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Oxiracetam combined with Danhong treatment of senile cerebral infarction, can significantly improve the patient’s neurological deficit score and hemorheology, improve clinical efficacy and reduce the incidence of adverse reactions.