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对受照后的核燃料萃取加工时,存在着~(238)Pu和磷酸三丁酯一起进入人体的危害.因此,有必要研究~(238)Pu磷酸三丁酯络合物吸入后早期的代谢和从体内排出的情况.成年Wistar雌鼠一次吸入~(238)Pu(NO_3)_4气溶胶(吸30～40分钟,对照组)或~(238)Pu磷酸三丁酯络合物气溶胶(吸50分钟,实验组),两者初始肺负荷分别为13和1.4kBq.吸入后至64天不同时间肺、血、骨、肝、肾中的钚含量及8天内的钚排泄量均以通用放射化学方法测定.结果表明,磷酸三丁酯(TBP)基本上没有改变~(238)Pu在体内的分布,钚依然优先滞留于骨胳并随着时间的推移更著.TBP对钚的排泄方式没有影响,钚仍主要由粪排出.TBP使钚的吸收率提高,因而显著加快钚在体内的沉积和排出速度,并使钚的吸
In the process of extraction and extraction of irradiated nuclear fuel, there is the danger of 238Pu and tributyl phosphate entering the human body together. Therefore, it is necessary to study the early metabolism of 238Pu tributyl phosphate complex after inhalation (238) Pu (NO_3) _4 aerosol (30 to 40 minutes aspiration group) or ~ (238) Pu tributyl phosphate complex aerosol 50 minutes, the experimental group), the initial lung load of the two were 13 and 1.4kBq.Plutonium levels in the lung, blood, bone, liver, kidney and pu-plutonium excretion within 8 days after inhalation to 64 days were general-purpose The results showed that TBP did not change the distribution of ~ (238) Pu in the body, and plutonium still preferentially resided in the skeletal bone and became more prominent with the passage of time.The excretion of plutonium by TBP With no effect, plutonium is still largely excreted, and TBP increases the rate of absorption of plutonium, thereby significantly accelerating the rate of deposition and discharge of plutonium in the body and accelerating plutonium absorption