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目的:探讨位于核因子κB1(nuclear factor kappa subunit 1,NF-κB1)基因内含子区的多态性位点rs4648127与中国人群胃癌易感性的关联。方法:采用病例-对照研究,以363例胃癌患者和506例年龄、性别相匹配的健康对照者作为研究对象,用高分辨率熔解曲线(high resolution melting,HRM)方法对rs4648127多态位点进行基因分型,最后通过SPSS 19.0统计分析软件对分型数据进行统计分析。结果:rs4648127位点的突变基因型CT与胃癌易感性有显著的相关性(P=0.005,OR=0.45,95%CI=0.25~0.79)。根据吸烟及饮酒等因素分层分析显示,在年龄组、性别组、非吸烟组及非饮酒状态组中均体现出CT基因型能够显著降低胃癌易感性风险(P<0.05)。结论:NF-κB1多态性位点rs4648127能够显著降低中国人群胃癌易感性。
Objective: To investigate the association of rs4648127, a polymorphism site located in the intron region of the nuclear factor kappa subunit 1 (NF-κB1) gene, with susceptibility to gastric cancer in Chinese population. METHODS: A case-control study of 363 gastric cancer patients and 506 age and sex matched healthy controls was performed using the high resolution melting (HRM) method for rs4648127 polymorphic loci Genotyping, and finally statistical analysis of typing data using SPSS 19.0 statistical analysis software. Results: The mutation genotype CT at rs4648127 was significantly associated with gastric cancer susceptibility (P = 0.005, OR = 0.45, 95% CI = 0.25-0.79). Stratified analysis of factors such as smoking and drinking showed that CT genotypes could significantly reduce the risk of gastric cancer susceptibility in the age group, sex group, non-smoking group and non-alcohol group (P <0.05). Conclusion: rs4648127, a polymorphism site of NF-κB1, can significantly reduce gastric cancer susceptibility in Chinese population.