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目的：探讨自发性腹膜炎腹水粒细胞集落刺激因子（Ｇ－ＣＳＦ）测定的临床意义。方法：应用酶联免疫技术测定２５ 例自发性腹膜炎和２５ 例非细菌感染性腹水患者腹水中的Ｇ－ＣＳＦ。结果：在自发性腹膜炎患者腹水中Ｇ－ＣＳＦ阳性率（９２％ ）明显高于非细菌感染性腹水中的阳性率（４％ ），其差异有显著统计学意义（Ｐ＜ ０．００１）。其敏感性为９２％ ，特异性为９６％ 。并且腹水中的Ｇ－ＣＳＦ水平明显高于血清中的水平。随着自发性腹膜炎感染的控制，腹水Ｇ－ＣＳＦ水平逐渐降至正常。结论：腹水Ｇ－ＣＳＦ检测可有效区别自发性腹膜炎与非感染性腹水，对自发性腹膜炎的早期诊断和疗效观察均具有临床实际应用价值
Objective: To investigate the clinical significance of spontaneous ascites granulocyte colony-stimulating factor (G-CSF) determination. Methods: The G-CSF in ascites of 25 patients with spontaneous peritonitis and 25 patients with non-bacterial ascitic fluid was measured by enzyme-linked immunosorbent assay. Results: The positive rate of G-CSF in ascites of patients with spontaneous peritonitis was significantly higher than that in non-bacterial ascites (92%). The difference was statistically significant (P <0.001). Its sensitivity is 92% and its specificity is 96%. And the level of G-CSF in ascites was significantly higher than that in serum. With the control of spontaneous peritonitis infection, ascites G-CSF levels gradually decreased to normal. Conclusion: Ascitic fluid G-CSF test can effectively distinguish between spontaneous peritonitis and non-infectious ascites, the early diagnosis and treatment of spontaneous peritonitis have clinical value