根据Parkin等[1]报道,预计到2020年,全球恶性肿瘤新发病例和死亡病例将达到2 000万和1 200万,癌症即成为人类健康的第一杀手。传统的放、化疗疗效都非常有限,且常伴有难以忍受的不良反应,因此迫切需要新的诊治手段[2]。100多年前即已发现肿瘤周围有新生血管,肿瘤血管生 According to Parkin et al. [1], it is estimated that by 2020, 20 million new cases and 12 million new cases of malignant tumors will occur worldwide, and cancer will become the number one killer of human health. The traditional radiotherapy and chemotherapy are very limited, and often accompanied by intolerable adverse reactions, so the urgent need for new treatment methods [2]. More than 100 years ago that tumor has been found around the neovasculature, tumor angiogenesis