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急性心内膜炎最常见的病因是金黄色葡萄球菌。通过试管内和动物体内的研究发现,一种β—内酰胺环类抗菌素和一种氨基糖甙类抗菌素合并应用,可以增加对微生物的杀灭力。这种发现引起了临床应用中的争论。因而我们将25例金黄色葡萄球菌心内膜炎的患者任意分为两组,单独或合并静脉内给药。结果两组平均退热天数相同,单独用药组为6.3天(SEM,1.49d)。合并组为6.6天,(SEM,1.02d)两组均无细菌学的失败或复发,患者不需行心脏瓣膜手术,也未发生死亡。因此,单独用一种适当的β内酰环类抗菌素静脉注射治疗金黄色葡萄球菌心内膜炎是妥当和适宜的。
The most common cause of acute endocarditis is Staphylococcus aureus. Through in vitro and in vivo studies, it has been found that the combination of a β-lactam cyclic antibiotic and an aminoglycoside antibiotic increases the killing of microorganisms. This discovery caused controversy in clinical applications. Therefore, we randomly divided 25 patients with Staphylococcus aureus endocarditis into two groups, either intravenously or alone. Results The average number of days for the two groups was similar, with 6.3 days (SEM, 1.49 days) in the drug-alone group. Patients in the combined group had a 6.6-day (SEM, 1.02-d) absence of bacteriological failure or recurrence, and did not require heart valve surgery or death. Therefore, intravenous injection of an appropriate β-lactone antibiotic alone for the treatment of Staphylococcus aureus endocarditis is appropriate and appropriate.