在热带和亚热带地区的发展中国家,钩虫感染是引起人肠道丢失血液和缺铁性贫血的主要因素之一。钩虫引起的缺铁性贫血主要是因为成虫在肠道的吸血活动以及咬附部位粘膜伤口的渗血不止引起。钩虫吸血时,其头腺分泌一种具有抗血凝活性的物质延缓血液凝固、方便其吸血。自从1904年Loeb发现犬钩虫提取物有抗凝血作用以后,长久以 Hookworm infection is one of the major causes of intestinal blood loss and iron-deficiency anemia in developing countries in the tropics and subtropics. Hookworm caused by iron deficiency anemia is mainly due to adult blood vessels in the intestinal vomiting and mucosal wounds at the site of bleeding caused by bleeding. Hookworm vampire, the gland secretion of a kind of anti-clotting activity of substances delay blood coagulation, to facilitate its vampire. Loeb has long been known to have been tested for anti-clotting effects by Loeb in 1904