近日,来自布莱根妇女医院的研究人员通过研究发现了两个治疗动脉疾病(比如动脉粥样硬化)的潜在药物靶点,通过利用蛋白质组学对大量分子进行筛选,研究者鉴别出了两种PARP家族蛋白:PARP9和PARP14,这两种蛋白或许能够作为巨噬细胞激活的调节子,而巨噬细胞的激活同动脉疾病的发生直接相关,相关研究刊登于国际杂志Nature Communications上。虽然巨噬细胞的激活机制至今仍然没有被完全阐明,此前有研究表明,巨噬细胞在动脉粥样硬化和其血栓并发症发生过程中扮演着重要作 Researchers from Brigham and Women’s Hospital recently discovered two potential drug targets for the treatment of arterial disease, such as atherosclerosis. By screening large numbers of molecules using proteomics, the researchers identified two The PARP family of proteins, PARP9 and PARP14, may both act as regulators of macrophage activation, and macrophage activation is directly linked to the development of arterial disease, a study published in the journal Nature Communications. Although the activation of macrophages has not yet been fully elucidated, studies have shown that macrophages play an important role in the pathogenesis of atherosclerosis and its thrombosis