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妊娠期胎盘滋养层细胞、子宫蜕膜细胞、肌层细胞及羊水中均有转化生长因子β(TGFβ)表达。TGFβ对滋养层细胞增殖、分化及浸润、对子宫内膜功能、子宫前列腺素E_2(PG E_2)分泌,对滋养层细胞和蜕膜细胞内分泌、免疫及黏附分子表达功能及胚胎发育均有重要的调节作用。TGFβ表达失调可能与宫内发育迟缓、先兆子痫、习惯性流产、滋养层细胞恶性肿瘤等妊娠疾病的发病机制有关
Gestational placental trophoblastic cells, uterine decidual cells, myometrial cells and amniotic fluid have transforming growth factor β (TGFβ) expression. The proliferation, differentiation and infiltration of trophoblast cells by TGFβ are important for endometrial function, secretion of prostaglandin E_2 (PG E_2), endocrine function of trophoblast and decidual cells, immune function, adhesion molecule expression and embryonic development Regulatory effect. The dysregulation of TGFβ may be related to the pathogenesis of gestational diseases such as intrauterine growth retardation, preeclampsia, habitual abortion and trophoblastic malignancies