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目的:检测类风湿关节炎(RA)血清中的抗环瓜氨酸肽(抗-CCP)抗体对RA诊断的灵敏度和特异性及其临床应用价值。方法:对87例RA患者,其他类风湿疾病患者76例和41例健康人检测抗-CCP抗体和类风湿因子(RF),并分析它们的相关性。结果:87例RA患者中抗-CCP灵敏度83.9%,特异性94.7%,抗-CCP抗体和RF具有相关性。结论:抗-CCP抗体是诊断RA的一个很有价值的指标。
Objective: To detect the sensitivity, specificity and clinical value of anti-cyclic citrullinated peptide (anti-CCP) antibodies in the serum of rheumatoid arthritis (RA) for the diagnosis of RA. Methods: The anti-CCP antibody and rheumatoid factor (RF) in 87 patients with RA, 76 patients with other rheumatic diseases and 41 healthy people were detected and their correlations were analyzed. Results: In 87 RA patients, the anti-CCP sensitivity was 83.9% and the specificity was 94.7%. The anti-CCP antibody was correlated with RF. Conclusion: Anti-CCP antibody is a valuable indicator for the diagnosis of RA.