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冠状动脉粥样硬化的发病机制有多种学说,包括脂质浸润学说、动脉平滑肌细胞克隆学说、血栓形成学说、损伤反应学说等。但是,近年来的大量研究证实动脉粥样硬化也是一种慢性炎症性疾病~[1],炎症反应在动脉粥样硬化的起始、发展和并发症中都起到关键性作用~[2]。其中炎性因子白介素17(IL-17)在动脉粥样硬化以及血栓形成,加速动脉硬化进程中起重要作用,并可能在动脉硬化斑块的不稳定性中起驱动作用~[3]。
The pathogenesis of coronary atherosclerosis has many theories, including lipid infiltration theory, arterial smooth muscle cell cloning theory, thrombosis theory, damage response theory. However, a large number of studies in recent years have confirmed that atherosclerosis is also a chronic inflammatory disease [1]. The inflammatory response plays a key role in the initiation, development and complications of atherosclerosis [2] . IL-17 plays an important role in the process of atherosclerosis, thrombosis and accelerated atherosclerosis, and may play a role in the instability of atherosclerotic plaque [3].