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各种细胞因子、化学因子和粘附分子(adhesionmolecules)在动物实验性脑缺血时均有表达,缺血性脑卒中病人的体液中这些成分也增高。白介素-6(IL-6)是人血清中能测出的少数细胞因子之一。受炎症前(preinflammatory)刺激产生的肿瘤坏死因子-γ(TNF-γ)和IL-6显然反映急性脑卒中病人处于炎症前状态。转化型生长因子-β(TGF-β)是一种免疫调节细胞因子。作者连续测定急性脑卒中病人的IL-6和TGF-β,同时测定S-100蛋白,该蛋白是迄今最能反映脑损伤程度
Various cytokines, chemokines and adhesionmolecules are expressed in experimental cerebral ischemia in animals, and are also increased in body fluids of patients with ischemic stroke. Interleukin-6 (IL-6) is one of the few cytokines detectable in human serum. Tumor necrosis factor-gamma (TNF-gamma) and IL-6, produced by preinflammatory stimuli, clearly reflect that patients with acute stroke are pre-inflammatory. Transforming growth factor-β (TGF-β) is an immunomodulatory cytokine. The authors continuously measure IL-6 and TGF-β in patients with acute stroke and determine the S-100 protein, which is by far the most representative of the extent of brain injury