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目的观察辛伐他汀对慢性心衰的作用。方法74例慢性心力衰竭患者,随机分为辛伐他汀治疗组(42例)和对照组(31例),对照组给予强心、利尿、扩血管治疗,治疗组在此基础上加用辛伐他汀,剂量为20mg,每晚1次,疗程6个月,测定左室射血分数(LVEF)、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD),统计2组治疗后症状改善率、再住院率、死亡率。结果辛伐他汀治疗组与对照组比较,治疗后2组左室射血分数均有所提高,左室收缩末内径均有缩小,但辛伐他汀组明显,与对照组比较差异有统计学意义;治疗后与治疗前比较,辛伐他汀组症状改善率、心衰再住院率、死亡率下降更明显,2组比较差异有统计学意义。结论辛伐他汀能改善慢性心衰患者的心功能、并使心衰住院率、死亡率有进一步下降。
Objective To observe the effect of simvastatin on chronic heart failure. Methods 74 patients with chronic heart failure were randomly divided into simvastatin treatment group (n = 42) and control group (n = 31). The control group was treated with cardiotonic, diuretic and vasodilator therapy. The treatment group was given simvastatin Statin, 20mg, once a night, for 6 months. The left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) Improvement rate, rehospitalization rate, mortality rate. Results Compared with the control group, the left ventricular ejection fraction increased and the mean diameter of left ventricular end-systole decreased after simvastatin treatment, but the difference between simvastatin group and control group was statistically significant ; After treatment, compared with before treatment, simvastatin group symptom improvement rate, heart failure rehospitalization rate, mortality decreased more significantly, the difference between the two groups was statistically significant. Conclusion Simvastatin can improve cardiac function in patients with chronic heart failure, and further reduce the hospitalization rate and mortality of heart failure.