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目的探讨自体造血干细胞移植(AHSCT)治疗系统性红斑狼疮(SLE)的临床疗效。方法对分别合并狼疮脑、狼疮性肾炎、股骨头坏死的8例SLE患者,采集用环磷酰胺和重组人粒细胞集落刺激因子动员后获得的外周血造血干细胞,经马利兰、环磷酰胺、抗人淋巴细胞球蛋白、甲基强的松龙预处理后,回输自体外周血干细胞,用重组人粒细胞集落刺激因子刺激恢复造血,观察AHSCT前后免疫指标和临床表现。结果AHSCT后患者的临床症状和体征基本消失,狼疮相关抗体转阴,免疫指标基本正常。结论AHSCT治疗SLE短期、中期疗效较好,远期疗效还需长期随访观察。
Objective To investigate the clinical efficacy of autologous hematopoietic stem cell transplantation (AHSCT) in the treatment of systemic lupus erythematosus (SLE). Methods Eight SLE patients with lupus nephritis, lupus nephritis and femoral head necrosis were collected. Peripheral blood hematopoietic stem cells obtained after mobilization with cyclophosphamide and recombinant human granulocyte colony-stimulating factor were collected and analyzed by MSL, cyclophosphamide, After pretreatment with human lymphocyte globulin and methylprednisolone, autologous peripheral blood stem cells were transfused and hematopoietic cells were stimulated with recombinant human granulocyte colony-stimulating factor. The immune indexes and clinical manifestations before and after AHSCT were observed. Results The clinical symptoms and signs of patients after AHSCT disappeared, lupus-related antibodies turned negative and the immune indexes were basically normal. Conclusion AHSCT is effective in short-term and mid-term treatment of SLE. Long-term follow-up of long-term follow-up is still needed.