灵芝在我国历代著名本草书籍中均有论述,古代医药学家们认为它是一种扶正固本、滋补强壮的药物,能治疗多种疾病。近年来,由于灵芝注射液广泛地用于临床,过敏反应相继出现,轻者发生荨麻疹,重者引起过敏性休克。为此,我们对灵芝注射液不同生产工艺的样品,进行了豚鼠过敏试验,以视其免疫原物质是否被除去,从而改进工艺,提高质量。同时在过敏试验方法学上亦进行了探讨,比较了不同致敏方法,包括不同的致敏剂、致敏时间、致敏次数,找出血清中产生高浓度抗体效价的条件,以提高过敏试验方法的灵敏性。 Ganoderma lucidum has been discussed in all the famous Chinese herbal medicine books in ancient times. Ancient medical scientists think it is a kind of medicine that helps strengthen the body, strengthens and strengthens, and can cure a variety of diseases. In recent years, as Ganoderma Injection has been widely used in clinics, allergic reactions have emerged one after another. Urticaria occurs in the light, and anaphylactic shock is caused in severe cases. To this end, we performed guinea pig allergy tests on samples of different production processes of Ganoderma Injection to see if the immunogenic substances were removed, thereby improving the process and improving the quality. At the same time, allergy test methods were also discussed to compare different sensitization methods, including different sensitizers, sensitization time, number of sensitization, and to find out conditions for producing high concentrations of antibody titer in serum to increase allergy. Sensitivity of test methods.