目的　研究胰岛素样生长因子 (IGFs)对胎儿组织增殖和分化的作用。方法　应用免疫组化 ABC法对16至 2 4周胎龄肝、肾、肾上腺、脾、胸腺等组织 IGF— I阳性细胞进行定位研究。结果　胎儿期内 ,以上器官中均有IGF— I阳性细胞存在 ,不同个体和器官其阳性细胞的数量、反应强弱和表达情况有差异。结论　在人胎发育过程中 ,这些器官组织均能表达 IGF— I,对其增殖分化起着自分泌和旁分泌的作用 Objective To study the effect of insulin-like growth factor (IGFs) on the proliferation and differentiation of fetal tissues. Methods Immunohistochemical ABC method was used to study the IGF-I positive cells in the liver, kidney, adrenal gland, spleen and thymus from 16 to 24 weeks. Results During the fetal period, there were IGF-I-positive cells in all the above organs. The number of positive cells and the reaction intensity and expression in different organs and organs were different. Conclusion During the development of human fetus, these organs and tissues can express IGF-I, play an autocrine and paracrine role in their proliferation and differentiation