隐球菌病(cryptococcosis)是新生隐球菌(cryptococcus neoformans)引起的一种急性、亚急性或慢性真菌病,脑、肺、骨或皮肤最易感染。近年来,隐球菌病的发病率逐渐增高,免疫功能正常和免疫功能受损的宿主均可感染,以隐球菌脑膜炎最常见,其次是肺和皮肤的感染。一、病原学1894年 Sanfelice 首先在桃汁中分离到一种新的真菌,将其命名新型酵母菌,直到1950年 Benham最终将其命名为新生隐球菌(C.neoformans)。隐球菌属有17个种和9个变种,是一种腐物寄生性酵母 Cryptococcosis is an acute, subacute, or chronic fungal disease caused by cryptococcus neoformans and is the most susceptible to brain, lung, bone or skin infections. In recent years, the incidence of cryptococcosis gradually increased, normal immune function and immunocompromised host can be infected with cryptococcal meningitis is the most common, followed by lung and skin infections. I. Etiology Sanfelice first isolated a new fungus in peach juice in 1894 and named it a new yeast until Benham finally named it C.neoformans in 1950. Cryptococcus genus has 17 species and 9 varieties, is a saprophytic parasitic yeast