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作者报告一例27岁男性,在接种第3剂甲型肝炎疫苗后发生神经系统症状。先出现感觉不适,发音不清,逐渐发展为语无伦次、嗜睡,入院时反应消失,双侧瞳孔扩大,面部表情异常,臂腿活动异常。但头部CT、脑脊液、血液学、生化和毒理学检查正常。 该病例无药物史,初步诊断为脑炎,故开始静注无环鸟苷(acyclovir)。随后脑电图检查显示无脑炎的证据,脑部磁共振检查亦正常。18小时后病人开始恢复,48小时后完全恢复。24小时后停用无环鸟苷。微生物培养阴性。
The authors report a 27-year-old man who developed neurological symptoms after receiving a third dose of Hepatitis A vaccine. First appeared discomfort, unclear pronunciation, and gradually developed into incoherent, lethargy, admission reaction disappeared, bilateral pupils dilated, facial expression abnormalities, abnormal leg movements. However, head CT, cerebrospinal fluid, hematology, biochemistry and toxicology were normal. The case no drug history, the initial diagnosis of encephalitis, it began intravenous acyclovir (acyclovir). Followed by electroencephalography showed no evidence of encephalitis, brain magnetic resonance imaging is normal. After 18 hours, the patient started to recover and recovered completely after 48 hours. Acycline guanosine is discontinued after 24 hours. Microbial culture negative.