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目的:研究贞冰口溃宁含片抗炎镇痛促进溃疡愈合的作用。方法:采用巴豆油致小鼠耳廓肿胀法观察其抗炎作用,醋酸致小鼠扭体法观察其镇痛作用,醋酸致金黄地鼠口腔溃疡法观察其促进溃疡愈合的作用。结果:贞冰口溃宁含片能明显减轻小鼠耳廓肿胀度(P<0.01);减少小鼠扭体次数(P<0.05);显著缩小溃疡直径(P<0.01或P<0.05),减轻炎症反应。结论:贞冰口溃宁含片具有抗炎、镇痛、促进溃疡愈合的作用。
Objective: To study the effect of Zhenbingkoukouning tablet on anti-inflammatory analgesia and promoting ulcer healing. Methods: Anti-inflammatory effect was observed by swelling of mouse auricle with croton oil. The analgesic effect was observed by writhing method in mice induced by acetic acid. The effect of acetic acid-induced hamster oral ulcer on the healing of ulcer was observed. Results: Zhenbingkou Kuining tablets can significantly reduce the auricle swelling of mice (P <0.01), reduce the number of writhing in mice (P <0.05), significantly reduce the diameter of ulcer (P <0.01 or P <0.05) Reduce inflammation. Conclusion: Zhen Bing Kou Kui Ning lozenges have anti-inflammatory and analgesic effects and promote ulcer healing.