许多慢性肝病发展到终末阶段形成肝纤维化进而转变成肝硬化,严重威胁人们的健康。目前临床治疗肝纤维化的有效方法是肝移植,但由于供体缺乏、免疫排斥和治疗费用昂贵等诸多缺陷,这种疗法并不是一种理想的治疗途径。近些年细胞治疗研究火热,间充质干细胞作为一种来源广泛、可定向迁移和多向分化的治疗载体,在肝纤维化治疗上具有广阔的应用前景。本文对间充质干细胞治疗肝纤维化的现状进行归纳,并对其可行性、局限性及应用前景进行分析。 Many chronic liver disease to the terminal stage of the formation of liver fibrosis and then transformed into cirrhosis, a serious threat to people’s health. At present, the effective method of clinical treatment of liver fibrosis is liver transplantation, but due to the lack of donor, immune rejection and high cost of treatment and many other defects, this therapy is not an ideal therapeutic approach. In recent years, cell therapy research is hot, mesenchymal stem cells as a widely-available, targeted migration and multidirectional differentiation of the therapeutic vector, in the treatment of liver fibrosis has broad application prospects. This article summarizes the current status of mesenchymal stem cells in the treatment of liver fibrosis, and analyzes its feasibility, limitations and application prospects.