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目的:评价促红细胞生长素(EPO)对慢性心衰并轻度贫血病人运动贮量的作用。方法:42例中、重度慢性心衰(NYHAⅢ～Ⅳ级)合并轻度贫血病人,随机分入EP()治疗组和对照组。两组均予常规药物治疗,EPO治疗组加用EPO及铁剂注射治疗,至血红蛋白浓度达目标值(120 g/L)或治疗时间达四个月。结果:于治疗四月后,EPO 治疗组运动峰耗氧量及6 mm步行距离较治疗前有显著改善(P<0.05);对照组上述指标无明显变化(P>0.05)。结论:EPO可显著改善合并轻度贫血的中、重度慢性心衰病人的运动贮量。
Objective: To evaluate the effect of erythropoietin (EPO) on exercise reserve in patients with chronic heart failure and mild anemia. Methods: Forty-two patients with moderate and severe chronic heart failure (NYHA Ⅲ ~ Ⅳ) with mild anemia were randomly divided into EP (treatment group) and control group. The patients in both groups were treated with conventional drugs. The patients in EPO group were treated with EPO and iron injection until the hemoglobin concentration reached the target value (120 g / L) or the treatment time was up to four months. Results: After 4 months of treatment, the exercise peak oxygen consumption and walking distance of 6 mm in EPO treatment group were significantly improved compared with that before treatment (P <0.05). There was no significant change in the above indexes in the control group (P> 0.05). Conclusion: EPO can significantly improve the exercise reserve of moderate and severe chronic heart failure patients with mild anemia.