在离体大鼠心脏灌流模型上,发现用高[Ca~(2+)](4.5mmol/L)、高[K~+](8.7mmol/L)或自由基发生系统灌流,显著增加心肌对脂质体的摄取。静脉注射与大鼠心肌细胞抗体共价结合的脂质体,显著增强了脂质体趋心肌组织的靶向性。用脂质体携载超氧化物歧化酶(superoxide dismutase,SOD)治疗大鼠心肌缺血-再灌注损伤,其疗效远优于单用SOD治疗。实验结果表明,脂质体作为药物载体治疗缺血性心脏病可能具有临床应用前景。 In a perfused rat heart perfusion model, it was found that a high [Ca 2+ ](4.5 mmol/L), high [K+] (8.7 mmol/L), or free radical perfusion system significantly increased the myocardium Uptake of liposomes. Intravenous injection of liposomes covalently bound to rat cardiomyocyte antibodies significantly enhances the targeting of liposomes to the myocardium. Superoxide dismutase (SOD) carried by liposomes was used to treat myocardial ischemia-reperfusion injury in rats. The therapeutic effect of SOD was much better than SOD alone. The experimental results show that liposomes as a drug carrier for the treatment of ischemic heart disease may have clinical application prospects.