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目的研究Z蛋白(PZ)和小儿脑性瘫痪之间的关系。方法随机选取脑瘫患儿40例(脑瘫组)、缺氧缺血性脑病患儿30例(HIE组)、脑瘫高危新生儿20例(脐血组)以及各组正常对照健康儿童20例,用酶联免疫吸附试验法(ELISA法)测定各组血浆中PZ的含量(脐血组测定脐血浆PZ含量)。结果脐血组PZ水平高于脐血对照组(P<0.05);脑瘫组和HIE组血浆PZ水平均明显高于各自对照组(P<0.01);HIE组血浆PZ水平显著高于脐血组(P<0.05);脑瘫组血浆PZ水平明显高于HIE组(P<0.05)。结论 PZ在小儿脑瘫的演变过程中呈现动态变化的规律,可在一定程度上为临床早期诊断、治疗提供参考依据。
Objective To study the relationship between Z protein (PZ) and pediatric cerebral palsy. Methods Forty children with cerebral palsy (cerebral palsy group), 30 children with hypoxic-ischemic encephalopathy (HIE group), 20 high-risk newborns with cerebral palsy (cord blood group) and 20 normal healthy children Enzyme-linked immunosorbent assay (ELISA) was used to determine the content of PZ in plasma (cord blood plasma PZ was measured in cord blood group). Results The levels of PZ in cord blood group were significantly higher than those in cord blood group (P <0.05). The levels of plasma PZ in cerebral palsy group and HIE group were significantly higher than those in control group (P <0.01). Plasma PZ level in HIE group was significantly higher than that in cord blood group (P <0.05). Plasma PZ level in cerebral palsy group was significantly higher than that in HIE group (P <0.05). Conclusion PZ showed a regular pattern of dynamic changes in the development of children with cerebral palsy, which can provide a reference for clinical diagnosis and treatment to a certain extent.