论文部分内容阅读
目的建立用于测试颅内支架性能的颈内动脉虹吸段动物模型。方法使用快速原型及脱蜡技术建立6只颈内动脉虹吸段约束装置。手术暴露并游离6只犬双侧颈总动脉。左侧颈总动脉近端暂时性夹闭,远端结扎并沿结扎点近侧切断。右侧颈总动脉远端暂时性夹闭,近端结扎并沿结扎点远侧切断。左侧颈总动脉近侧段穿过塑型装置,并与右侧颈总动脉远侧游离段端端吻合。术后1、2周、1个月血管造影,视觉评估虹吸段模型形态,血管通畅,吻合口狭窄及附壁血栓形成情况。结果所有实验犬均能耐受手术,无一只死亡或出现神经功能障碍。建模平均手术时间90min。术后1、2周、1个月血管造影,显示虹吸段模型空间结构与其人体原形高度相似,2例发生吻合口狭窄,1例吻合口附壁血栓形成。所有模型虹吸段随访中均保持通畅。结论采用体外约束装置,手术建立虹吸段模型切实可行,该模型具有高度可重复性、可靠性,可用于测试神经血管内材料。
Objective To establish an animal model of internal carotid artery siphon for testing the performance of intracranial stents. Methods A rapid prototyping and dewaxing technique was used to establish six siphon restriction devices. Six dogs were surgically exposed and free from the common carotid artery. Proximal left common carotid artery occlusion, distal ligation and cut off along the proximal point of ligation. Right distal common carotid artery occlusion, proximal ligation and cutting off along the ligation point. The proximal segment of the common carotid artery passes through the plastic device and is anastomosed to the distal segment of the distal common carotid artery. One, two weeks and one month postoperative angiography, visual assessment of siphon section model morphology, vascular patency, anastomotic stricture and mural thrombosis. Results All dogs were able to tolerate surgery without any death or neurological dysfunction. Modeling the average operation time 90min. The angiographic results at 1, 2 weeks and 1 month after operation showed that the spatial structure of the siphon segment model was highly similar to that of the human body. The anastomotic stenosis occurred in 2 cases and the anastomotic wall thrombosis occurred in 1 case. Siphon all models were followed during follow-up smooth. Conclusion It is practicable to establish a siphon model by using an in vitro restraint device. The model is highly reproducible and reliable and can be used to test the neurovascular material.