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目的探讨系统性红斑狼疮(SLE)患者血清免疫球蛋白和补体与年龄的关系。方法用免疫散射比浊法检测218例女性SLE患者及98名正常对照组女性的血清免疫球蛋白和补体,分析其与年龄的关系。结果女性SLE患者血清IgM水平(1.069±0.553)与正常对照组(1.161±0.443)相比,差异无统计学意义(P>0.05),血清IgG(17.515±5.845)和IgA(3.282±1.672)水平均显著高于正常对照组(12.668±2.918和2.315±0.750),但血清C3(0.895±0.327)和C4(0.156±0.086)水平均显著低于正常对照组(1.160±0.183和0.245±0.065),差异均有统计学意义(P均<0.01);血清IgA,C3和C4水平与年龄呈正相关(P均<0.05),而正常对照组免疫球蛋白和补体水平则与年龄无关(P均>0.05)。结论女性SLE患者血清IgG,IgA,C3和C4存在异常,IgA,C3和C4的异常与年龄相关。
Objective To investigate the relationship between serum immunoglobulin and complement in patients with systemic lupus erythematosus (SLE) and their age. Methods Serum immunoglobulin and complement were detected in 218 women with SLE and 98 normal controls by immunostaining turbidimetry and their relationship with age was analyzed. Results There was no significant difference in serum IgM levels between the female SLE patients (1.069 ± 0.553) and the normal controls (1.161 ± 0.443) (P> 0.05), serum IgG (17.515 ± 5.845) and IgA (3.282 ± 1.672) (12.668 ± 2.918 and 2.315 ± 0.750), but the levels of serum C3 (0.895 ± 0.327) and C4 (0.156 ± 0.086) were significantly lower than those of the normal control group (1.160 ± 0.183 and 0.245 ± 0.065) (P <0.01). Serum levels of IgA, C3 and C4 were positively correlated with age (P <0.05), while the levels of immunoglobulin and complement in the normal control group were not related to age (P> 0.05) ). Conclusion The serum levels of IgG, IgA, C3 and C4 in female patients with SLE are abnormal. The abnormalities of IgA, C3 and C4 are age-related.