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目的观察康艾注射液联合TP方案(紫杉醇+顺铂)方案治疗老年晚期非小细胞肺癌临床效果。方法将南阳医学高等专科学校第一附属医院收治的56例老年晚期肺癌患者随机分为观察组和对照组,两组各38例。两组均采用TP方案化疗,21 d为1个周期,共治疗2个周期,观察组自化疗开始时即联用复方康艾针,康艾注射液50 ml入5%葡萄糖注射液,静滴1次/d,每周期14 d,观察化疗2个周期后化疗近期疗效、患者化疗不良反应发生情况、骨髓抑制情况。结果观察组近期疗效(CR+RR)为53.83%,对照组为35.70%,差异无统计学意义,但观察组生活质量改善情况明显高于对照组,差异有统计学意义(P<0.05);对照组骨髓抑制情况、白细胞下降程度、贫血程度均较对观察组明显,差异有统计学意义(P<0.05);两组患者化疗后血小板改变情况差异无统计学意义;观察组化疗过程中消化道毒性总发生率为17.86%,且多为Ⅰ~Ⅱ度,对照组消化道不良反应发生率为42.86%,两组比较差异有统计学意义(P<0.05),化疗后体重增加情况观察组较对照组明显,差异统计学意义(P<0.05)。结论康艾注射液联合化疗、减轻化疗痛苦、改善患者生活质量。
Objective To observe the clinical effect of Kangai injection combined with TP regimen (paclitaxel + cisplatin) in the treatment of elderly patients with advanced non-small cell lung cancer. Methods 56 patients with advanced lung cancer admitted to the First Affiliated Hospital of Nanyang Medical College were randomly divided into observation group and control group, with 38 cases in each group. Both groups were treated with TP regimen, 21 days for 1 cycle, and 2 cycles for treatment. The observation group was treated with compound Kanga needle, Kangai injection 50 ml into 5% glucose injection, and intravenous infusion from the beginning of chemotherapy. 1 time/d, 14 days per cycle, observed the short-term efficacy of chemotherapy after 2 cycles of chemotherapy, the incidence of adverse chemotherapy reactions, and bone marrow suppression. Results The curative effect (CR+RR) was 53.83% in the observation group and 35.70% in the control group. The difference was not statistically significant, but the quality of life improvement in the observation group was significantly higher than that in the control group (P<0.05). The myelosuppression of the control group, leukocytopenia, and degree of anemia were all significantly higher than those of the observation group (P<0.05). There was no significant difference in platelet changes after chemotherapy between the two groups; the observation group was digested during chemotherapy. The total toxicities of road toxicity were 17.86%, and most of them were I~II degrees. The incidence of adverse reactions of the digestive tract in the control group was 42.86%. There was a statistically significant difference between the two groups (P<0.05). The observation group of weight gain after chemotherapy was observed. Compared with the control group, the difference was statistically significant (P<0.05). Conclusion Kangai injection combined with chemotherapy, reduce the pain of chemotherapy and improve the quality of life of patients.