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目的了解脑卒中高危人群同型半胱氨酸(Hcy)水平及其影响因素。方法采用整群抽样的方法,抽取南京市江宁区6 061例40岁以上常住居民进行初筛,共选取845例脑卒中高危人群进行复筛,通过χ~2检验和logistics探索Hcy升高的影响因素。结果 845例脑卒中高危人群中,Hcy升高604例(71.48%),其中男性325例,女性279例,男性Hcy升高率显著高于女性(84.86%vs.60.39%,P<0.001);年龄的增长、吸烟、饮酒、腹型肥胖、TG异常、高血压病史、脑卒中史等因素与Hcy升高之间均有统计学意义(P<0.05);多因素logistic逐步回归分析结果显示男性、年龄增加、TG升高是Hcy升高的重要危险因素。结论脑卒中高危人群Hcy水平明显升高,应采取有效的防控措施,降低心脑血管疾病的风险,提高居民生活质量。
Objective To investigate the level of homocysteine (Hcy) and its influencing factors in high-risk stroke population. Methods A total of 6 061 residents over the age of 40 in Jiangning district of Nanjing were enrolled in this study. A total of 845 high-risk groups of stroke were selected for screening, and the effect of elevated Hcy was explored by χ ~ 2 test and logistics factor. Results There were 604 cases (71.48%) of Hcy in 845 high risk stroke population, including 325 males and 279 females. The rate of Hcy in males was significantly higher than that in females (84.86% vs.60.39%, P <0.001). Age, smoking, drinking, abdominal obesity, TG abnormalities, history of hypertension, history of stroke and other factors were all significantly different from those of Hcy (P <0.05). Multivariate logistic regression analysis showed that men , Age, elevated TG is an important risk factor for Hcy increased. Conclusion The level of Hcy in high-risk stroke patients is obviously increased. Effective prevention and control measures should be taken to reduce the risk of cardiovascular and cerebrovascular diseases and improve the quality of life of residents.