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目的比较短期甘精胰岛素联合诺和灵R或二甲双胍强化治疗的疗效及对初诊的2型糖尿病患者(T2DM)胰岛β细胞功能的影响。方法对40例初诊的T2DM患者分别给予(A)甘精胰岛素与诺和灵R强化治疗,(B)二甲双胍加甘精胰岛素睡前皮下注射,4周后分析比较治疗前后FPG,2hPG、HbA1c、C肽、胰岛素释放试验的变化。结果治疗后两组FPG、2hPG、HbA1c均显著降低,差异有统计学意义(P<0.01);A组空腹及服糖后各时间点C肽与胰岛素水平均较治疗前有不同程度的升高,差异有统计学意义(P<0.01)。结论短期甘精胰岛素联合诺和灵R或二甲双胍治疗均有助于控制血糖,甘精胰岛素与诺和灵R联用还可明显改善初诊T2DM患者胰岛β细胞功能。
Objective To compare the effects of short-term glargine plus Novolin R or metformin intensive therapy and the effect on pancreatic β-cell function in newly diagnosed type 2 diabetic patients (T2DM). Methods Forty newly diagnosed T2DM patients were treated with (A) glargine and Novolin R intensively, (B) metformin plus insulin glargine injected subcutaneously at bedtime, and 4 weeks later, the levels of FPG, 2hPG, HbA1c, C peptide, changes in insulin release test. Results After treatment, the levels of FPG, 2hPG and HbA1c in both groups were significantly decreased (P <0.01), and the levels of C-peptide and insulin in group A were higher than those before treatment , The difference was statistically significant (P <0.01). Conclusion Short-term glargine plus Novolin R or metformin treatment are helpful to control blood sugar. Combined use of insulin glargine and Novolin R can significantly improve pancreatic β-cell function in newly diagnosed T2DM patients.