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目的 探讨肢体运动对早产儿骨矿物质含量(骨矿含量)的影响及临床意义。方法 用单光子吸收法(SPA)测定12例(运动组)早产儿运动4周前后桡骨骨矿含量值,同期检测血清钙(Ca)、磷(P)、碱性磷酸酶(AKP)、骨钙素(BGP)及甲状旁腺素(PTH)水平,并与11例(对照组)早产儿进行比较。结果 研究结束时运动组骨线密度(BMC)、骨面密度(BMD)值明显大于对照组水平(P均<0.01)。研究期间运动组BMC、BMD和骨宽度(BW)分别增加30%、15%和11%;对照组BW仅增加6.4%,而BMC、BMD则减少11%、14%。同期发现运动后血清BGP值明显高于运动前水平(P<0.05),对照组4周结束时PTH值明显大于开始时水平(P<0.05)。结论 运动可增加早产儿骨矿化作用,防止其骨质减少,这对预防早产儿代谢性骨病(MBDP)有重要意义。运动后骨矿含量的增加可能与增加骨形成、减少骨吸收有关
Objective To investigate the effect of limb movement on bone mineral content (bone mineral content) in preterm infants and its clinical significance. Methods The bone mineral content of radius in preterm infants of 12 cases (exercise group) before and after exercise for 4 weeks was determined by single photon absorption method (SPA). Serum Ca, P, AKP, BGP and PTH, and compared with 11 preterm infants (control group). Results At the end of the study, BMC and BMD in exercise group were significantly higher than those in control group (all P <0.01). BMC, BMD, and bone width (BW) were increased by 30%, 15%, and 11% in the exercise group during the study; those in the control group increased by only 6.4%, while those in the BMC and BMD decreased by 11% and 14%, respectively. During the same period, the serum BGP level was significantly higher than that before exercise (P <0.05). The PTH value at the end of the 4th week in the control group was significantly higher than that at the beginning (P <0.05). Conclusion Exercise can increase bone mineralization in preterm infants and prevent osteopenia, which is of great importance in preventing metabolic bone disease (MBDP) in preterm infants. Increased bone mineral content after exercise may be related to increasing bone formation and reducing bone resorption