【摘 要】
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Alzheimer\'s disease (AD) is a devastating neurodegenerative disease and the most common form of dementia in the elderly.Concurrent with an aging population,the incidence of AD has been rising steadily and become a global threat to public health [1].Unf
【机 构】
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Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine,
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Alzheimer\'s disease (AD) is a devastating neurodegenerative disease and the most common form of dementia in the elderly.Concurrent with an aging population,the incidence of AD has been rising steadily and become a global threat to public health [1].Unfortunately,there are currently no effective interventions that can cure AD or slow its progression,and recently finished clinical trials targeting brain amyloid-β (Aβ) accumulation have not succeeded in improving cognitive impairments in AD patients [1].Thus,it is necessary and urgent to identify alternative diseasemodifying strategies to alleviate AD pathophysiology.In this perspective article,we focus on glucagon-like peptide1 (GLP-1),specifically its natural cleavage product GLP-1 (9-36),as a potential therapeutic approach for AD.
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