论文部分内容阅读
目的:探讨宫颈癌的发生与性传播因子人乳头瘤病毒(HPV)16、18、35型、单纯疱疹病毒(HSV)2型、沙眼衣原体(CT)的关系。方法:应用聚合酶链反应(PCR)对195例宫颈癌的癌组织、51例非宫颈癌、32例健康妇女的正常宫颈组织进行检查。结果:宫颈癌HPV16、18、35型、HSV2型和CT的阳性率分别为:31.79%、30.77%和5.64%,非宫颈癌的阳性率分别为:3.92%、3.92%和1.96%,正常妇女的阳性率分别为:3.13%、6.24%和3.13%。宫颈癌组HPV16、18、35型及HSV2型明显高于非宫颈癌组和正常妇女组(P<0.001),而CT感染则无明显差异(P>0.05)。结论:宫颈癌的发生与HPV16、18、35型及HSV2型感染密切相关。
Objective: To investigate the relationship between the occurrence of cervical cancer and sex-transmitted human papillomavirus (HPV) type 16, 18, 35, herpes simplex virus (HSV) 2 and Chlamydia trachomatis (CT). Methods: The normal cervical tissues of 195 cases of cervical cancer, 51 cases of non-cervical cancer and 32 healthy women were examined by polymerase chain reaction (PCR). Results: The positive rates of HPV16, HPV18, HPV18, HSV2 and CT in cervical cancer were 31.79%, 30.77% and 5.64% respectively. The positive rates of non-cervical cancer were 3.92%, 3.92% and 1.96% The positive rates were 3.13%, 6.24% and 3.13% respectively. HPV16,18,35 and HSV2 in cervical cancer group were significantly higher than those in non-cervical cancer group and normal women (P <0.001), while CT infection showed no significant difference (P> 0.05). Conclusion: The incidence of cervical cancer is closely related to HPV16, HPV18, HPV18 and HSV2 infections.