论文部分内容阅读
目的评价口服特比萘芬片加外用益康唑乳膏短程联合疗法治疗足癣的疗效和安全性。方法采用随机数字表法将124名患者分为两组:试验组予特比萘芬片250mg口服,1次/d,联合益康唑乳膏外用,2次/d,共7d;对照组予益康唑乳膏外用,2次/d,同时口服维生素C片0.1g,1次/d,共28d。于停药时和停药后4周时观察临床疗效和真菌学疗效,停药后4周时观察复发情况。结果共有113例患者完成临床观察,脱落7例(试验组1例,对照组6例),剔除4例(对照组4例)。停药时两组相比试验组治愈率明显低于对照组(χ2=23.03,P<0.01),有效率及真菌清除率差异无统计学意义(χ2=0.33,P>0.05;χ2=0.03,P>0.05);停药后4周时两组相比试验组治愈率、有效率及真菌清除率均显著高于对照组(χ2=17.21,P<0.01;χ2=14.56,P<0.01;χ2=23.03,P<0.01);停药后4周时两组相比试验组复发率明显低于对照组(χ2=14.04,P<0.01);两组不良反应发生率相比差异无统计学意义(χ2=3.27,P>0.05)。结论口服特比萘芬片加外用益康唑乳膏短程联合疗法治疗足癣依从性和安全性高、疗效好。
Objective To evaluate the efficacy and safety of oral terbinafine plus topical econazole cream in treating tinea pedis. Methods Totally 124 patients were divided into two groups according to the random number table. The test group was treated with terbinafine 250 mg orally once daily for 7 days. The control group Econazole cream external use, 2 times / d, while oral vitamin C tablets 0.1g, 1 / d, a total of 28d. Clinical efficacy and mycological efficacy were observed at 4 weeks after discontinuation and 4 weeks after discontinuation. Recurrence was observed at 4 weeks after drug withdrawal. Results A total of 113 patients completed clinical observation, 7 cases were off (experimental group, 1 case, control group, 6 cases), 4 cases were excluded (control group, 4 cases). Compared with the control group, the cure rate of the two groups was significantly lower than that of the control group (χ2 = 23.03, P <0.01), and there was no significant difference in the effective rate and fungal clearance between the two groups (χ2 = 0.33, P> 0.05; P <0.01); χ2 = 14.56, P <0.01; χ2 = 14.56, P <0.05). After 4 weeks of treatment, the cure rate, effective rate and fungal clearance rate of the two groups were significantly higher than those of the control group = 23.03, P <0.01). The relapse rate of the two groups was significantly lower than that of the control group (χ2 = 14.04, P <0.01) at 4 weeks after discontinuation. There was no significant difference in the incidence of adverse reactions between the two groups (χ2 = 3.27, P> 0.05). Conclusion oral terbinafine plus topical Econazole cream short-course combination treatment of tinea pedis compliance and safety, good curative effect.