肝干细胞存在于成年肝脏Hering管 ,肝脏受损严重或肝细胞增殖受阻时激活、增殖、分化为肝细胞和胆管上皮细胞 ,与原发性肝癌的发生有重大关系。它也存在于胎肝 ,近来又发现一部分来源于骨髓及胰腺等肝外组织。多种因素调节其发育 ,在此过程中动态性表达一系列的表面标志 ,据其特异性标志进行分离、培养 ,可作为细胞替代疗法的细胞来源和基因疗法的受体细胞治疗肝病 Liver stem cells exist in the adult liver Hering tube, severe liver damage or blocked liver cell proliferation activated, proliferation, differentiation into hepatocytes and bile duct epithelial cells, and the occurrence of primary liver cancer have a major relationship. It also exists in fetal liver, and recently found that part of extrahepatic tissue derived from bone marrow and pancreas. A variety of factors regulate its development, in the process of dynamic expression of a series of surface markers, according to their specific markers for isolation and culture, can be used as a cell replacement therapy cell source and gene therapy of receptor cells for the treatment of liver disease