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目的通过观察2例胆囊癌肉瘤的临床病理学及免疫组化特点,结合文献探讨胆囊癌肉瘤的组织学特点。方法采用光镜及免疫组化对2例胆囊癌肉瘤标本进行观察分析。结果2例胆囊癌肉瘤患者均为成年女性。肿瘤呈菜花状或息肉状突入腔内,表面有坏死出血,肿瘤平均直径为3.5cm。光镜下胆囊癌肉瘤由上皮源性恶性肿瘤表现为腺癌或鳞状细胞癌及间叶源性恶性肿瘤混合组成,间叶成分则表现多样。免疫组化显示上皮源性恶性成分表达上皮细胞标记(EMA上皮+),而间叶源性恶性肿瘤表达间叶组织标记(如vimentin间叶+)。结论胆囊癌肉瘤是一罕见的高恶性肿瘤,多发生于中、老年女性,由癌和肉瘤两种成分混合组成。
Objective To observe the histopathological and immunohistochemical features of 2 cases of gallbladder carcinosarcoma and to explore the histological features of gallbladder carcinosarcoma with literature. Methods Two specimens of gallbladder carcinomas were observed by light microscopy and immunohistochemistry. Results 2 cases of gallbladder carcinosarcoma patients were all female. The tumor was cauliflower-like or polypoid into the cavity, the surface of necrotic hemorrhage, the average tumor diameter of 3.5cm. Light microscopic gallbladder carcinoma of the gallbladder by the epithelial malignant tumors showed adenocarcinoma or squamous cell carcinoma and mesenchymal malignant tumor mixed composition, melanin composition is varied. Immunohistochemistry showed epithelial-derived malignant components expressed epithelial markers (EMA epithelium +), while mesenchymal malignancies expressed mesenchymal markers (eg, vimentin mesenchyme +). Conclusion Gallbladder carcinosarcoma is a rare high-grade malignant tumor that occurs mostly in middle-aged and elderly women. It consists of two components: cancer and sarcoma.